Wrinkle-relaxing treatments have come a long way from the standard Botox injection. Neuromodulators, injectable treatments that temporarily relax muscles to smooth wrinkles, are entering a fresh phase with new products, techniques, and formulations on the horizon —one where smoother skin, refined pores, and even customized treatment timing are all possible. Here’s a look at the newest trends!

Intradermal Neuromodulators: Not Just for Wrinkles Anymore

Look beyond just targeting deep expression lines; the latest in neuromodulators is intradermal botulinum toxin injections, which are placed just below the skin’s surface instead of deep in the muscle. This technique is especially popular in Asia and is gaining interest in the U.S. for enhancing skin texture, minimizing pores, reducing oil, and calming rosacea. The method works to deliver botulinum toxin nearly parallel to the skin to subtly boost skin quality without freezing facial expressions.

Experts believe this technique could be a promising option for achieving smooth, radiant skin, though it currently requires a skilled touch and numbing cream due to its delicate application.

Meet the New Neuromodulators on the Block

While Botox has dominated for decades, new neuromodulators are offering exciting alternatives with unique benefits:

  1. Letybo: Known as a top choice in South Korea, Letybo has now hit the U.S. market with FDA approval for frown lines. Known for its strong efficacy and safety profile, it adds another option for consumers looking for botulinum toxin A treatments with reliable, lasting results.
  2. Daxxify: Approved in 2022, Daxxify is known for its long-lasting results, with some users experiencing effects for up to six months. Thanks to a peptide formulation that keeps the product stable longer, it’s a win for those looking to reduce appointment frequency while keeping wrinkles at bay.
  3. RelabotulinumtoxinA: Currently in development, this liquid, ready-to-use neuromodulator removes the need for reconstitution (mixing with saline before injection), a step that can introduce human error and reduce product consistency. This could simplify the injection process for both practitioners and patients, enhancing safety and reliability.

Rapid-Onset Neurotoxins: Ready for an Instant Glow-Up?

Imagine booking an appointment for Friday and enjoying full results by Saturday night. That’s the promise behind TrenibotulinumtoxinE, an emerging neurotoxin that delivers visible effects within a day, perfect for last-minute events. Though it only lasts about three to four weeks, it’s ideal for someone wanting a quick fix or a short-term trial with neuromodulators.

What Does the Future Hold?

With these new products and techniques, neuromodulators are becoming more customizable than ever. Whether you’re looking for longer-lasting effects, rapid results, or smoother skin without the “frozen” look, there’s something on the way that might be your perfect match. Dermatologists now have a wider toolkit to tailor treatments precisely to individual needs.

The world of neuromodulators is growing, expanding past traditional Botox treatments and promising more options for every aesthetic goal. Whether you’re a first-timer or a long-time fan, the next generation of neuromodulators could bring smoother, glowing skin with options that fit seamlessly into your lifestyle.