Evolysse: Advanced Hyaluronic Acid Filler

Evolysse is a new collection of injectable hyaluronic acid (HA) fillers designed to enhance facial volume, smooth wrinkles, and provide long-lasting rejuvenation. Developed by Evolus in partnership with Symatese, these fillers utilize Cold-X Technology, an advanced formulation process that preserves HA’s natural structure for improved lift, flexibility, and durability.

The first two FDA-approved products in the Evolysse line, Evolysse Form and Evolysse Smooth, are designed to treat moderate to severe facial wrinkles and volume loss while ensuring natural-looking, long-lasting results.

What Makes Evolysse Different?

Evolysse fillers are engineered to deliver a balance between smooth integration, natural movement, and structural support. Unlike traditional HA fillers, Cold-X Technology optimizes the viscoelastic properties of HA, allowing for better adaptability in facial tissues.

Key benefits of Evolysse include:

Advanced HA structure for seamless integration and tissue compatibility
Natural movement and flexibility, reducing stiffness in treated areas
Long-lasting results, with clinical trials showing effects for up to 12 months
Minimal swelling and downtime, allowing for quick recovery

Evolysse was designed to offer customized treatment options, ensuring that patients receive the most effective filler for their individual facial anatomy and aesthetic goals.

Evolysse Form: Structural Support and Deep Wrinkle Correction

Evolysse Form is a firm, high-density HA filler created for deep-set wrinkles, volume restoration, and facial contouring. It provides enhanced structural support, making it particularly effective in areas that require significant lifting power.

This filler is ideal for patients with noticeable volume loss or deep facial folds who want a long-lasting, non-surgical solution for facial rejuvenation. It can be used to:

Restore volume in the cheeks and midface, addressing age-related volume depletion
Define facial contours, particularly along the jawline and chin
Smooth deep wrinkles and folds, including nasolabial folds and marionette lines
Improve overall facial symmetry, creating a more youthful and balanced appearance

Evolysse Form is injected into the deeper layers of the skin, where it integrates with the tissue to provide natural-looking lift and structure. Clinical trials have demonstrated that its effects last up to 12 months, with high levels of patient satisfaction.

Evolysse Smooth: Subtle Refinement and Soft Tissue Integration

Evolysse Smooth is a softer, more flexible HA filler designed for delicate wrinkle correction and seamless blending with natural facial movements. It is formulated for areas where subtle refinement and smooth integration are essential, ensuring a soft, natural look.

This filler is best suited for individuals who want to:

Reduce moderate wrinkles and fine lines while maintaining facial expressiveness
Enhance hydration and skin quality, improving overall texture
Smooth dynamic facial areas, such as around the mouth and lips
Provide a refreshed appearance without excessive volume or stiffness

Because of its smooth, adaptable consistency, Evolysse Smooth integrates effortlessly into the skin, making it ideal for patients who want refined but noticeable improvements in facial appearance. Like Evolysse Form, it has been clinically tested to last up to 12 months, offering long-term results with minimal downtime.

How Do Evolysse Fillers Work?

Both Evolysse Form and Evolysse Smooth use hyaluronic acid to restore lost volume, smooth wrinkles, and enhance facial contours. The Cold-X Technology used in their formulation ensures that HA molecules retain their natural structure, allowing for improved integration, durability, and performance.

Evolysse fillers:

Replenish HA levels in the skin, restoring lost hydration and plumpness
Improve facial contouring by supporting the skin’s natural structure
Smooth wrinkles and folds, enhancing skin texture and elasticity
Provide immediate and long-lasting results, maintaining a youthful appearance

Who Is a Good Candidate for Evolysse?

Evolysse fillers are designed for individuals looking to correct facial wrinkles, volume loss, and signs of aging with a non-surgical injectable solution. These fillers can be customized to suit a variety of needs, from structural enhancement to subtle smoothing.

Ideal candidates include those who:

Have moderate to severe facial wrinkles, such as nasolabial folds
Want to restore lost volume in areas like the cheeks and jawline
Prefer a natural-looking filler that moves seamlessly with facial expressions
Are looking for a long-lasting alternative to traditional dermal fillers

Because Evolysse offers different formulations for different needs, a consultation with an experienced injector can help determine which filler is best suited for each individual.

How Long Do Evolysse Fillers Last?

Clinical studies have shown that Evolysse fillers provide noticeable, lasting results for up to 12 months. Longevity may vary depending on the individual’s metabolism, treatment area, and lifestyle factors.

The slow, natural breakdown of the HA gel ensures that results fade gradually, allowing patients to maintain their look with periodic touch-ups as needed.

Clinical Studies and Effectiveness

The safety and performance of Evolysse fillers were evaluated in a large-scale clinical trial, which compared Evolysse Form and Evolysse Smooth to a leading HA filler. Results showed:

Superior wrinkle reduction at multiple time points
No cases of delayed-onset nodules, confirming safety and predictability
Over 90% of patients reported satisfaction with their treatment results

These findings reinforce Evolysse’s effectiveness as a next-generation HA filler, offering long-lasting correction with an excellent safety profile.

The Future of HA Fillers with Evolysse

Evolysse represents a new era in HA filler technology, combining scientific innovation with aesthetic precision. Its Cold-X Technology sets a new standard for HA filler performance, longevity, and patient satisfaction, making it a valuable addition to non-surgical aesthetic treatments.

With the ability to customize treatment based on individual needs, Evolysse is paving the way for more refined, natural-looking results in facial aesthetics.