Lenisna: Hybrid Filler and Collagen Stimulator

Lenisna is an advanced injectable treatment designed for facial and body rejuvenation by restoring lost volume, tightening the skin, and improving overall elasticity. Unlike traditional dermal fillers, Lenisna works as both a biostimulator and filler, providing immediate volume enhancement while gradually increasing collagen and elastin production for long-term skin renewal.

This treatment is based on poly-D,L-lactic acid (PDLLA) and hyaluronic acid (HA), combining hydration, volumization, and collagen stimulation in a single formulation. Lenisna is particularly effective for treating deep wrinkles, sagging skin, and loss of facial structure, making it an excellent choice for individuals looking for natural yet long-lasting anti-aging results.

Development

Lenisna was developed in South Korea, a leading innovator in regenerative aesthetics. It was designed as an evolution of biostimulatory injectables, offering improved collagen stimulation with fewer side effects. Unlike older collagen stimulators that had a higher risk of nodule formation, Lenisna’s PDLLA microparticles are engineered for uniform dispersion, ensuring smoother results with a lower risk of complications.

This injectable has received CE and KFDA approvals, confirming its safety and efficacy for both facial and body rejuvenation. It is often compared to traditional dermal fillers, but its ability to improve skin quality from within makes it a more comprehensive approach to anti-aging.

How Lenisna Works

Lenisna provides a dual mechanism of action, making it a versatile option for both instant volume restoration and long-term structural improvement.

  • The hyaluronic acid component delivers immediate hydration and plumping, softening deep lines and adding volume to hollow areas.
  • The PDLLA microparticles act as a collagen stimulator, activating fibroblast cells to produce new collagen over time, leading to firmer, tighter, and more youthful-looking skin.
  • Over several months, Lenisna improves skin texture, elasticity, and thickness, addressing both aging-related volume loss and overall skin quality.

This combination of filling and biostimulation allows Lenisna to provide a more natural look compared to traditional fillers, which only add volume without improving skin structure.

Benefits of Lenisna

Lenisna offers comprehensive skin rejuvenation, making it suitable for individuals looking to smooth deep wrinkles, improve elasticity, and restore facial volume while ensuring long-lasting collagen production.

  • Improves facial contours by lifting and tightening sagging skin
  • Reduces deep wrinkles and folds, including nasolabial folds and marionette lines
  • Restores lost volume in hollow areas such as the cheeks, temples, and jawline
  • Enhances collagen and elastin production, leading to firmer, more resilient skin
  • Can be used on the neck, décolletage, and hands to improve skin quality in aging-prone areas
  • Minimal downtime compared to surgical procedures, with gradual but long-lasting results

Treatment Process and Longevity

Lenisna is injected into the deep dermis or subdermal layer, depending on the treatment area and desired effect. The procedure is performed in a series of two to three sessions, spaced about six to eight weeks apart, allowing the body to gradually generate new collagen while maintaining a natural look.

Results are immediately visible due to the hyaluronic acid component, but the full benefits develop over several months as collagen production increases. Most patients experience long-lasting effects for up to two years, with a maintenance session recommended to sustain results.

Comparison with Other Collagen Stimulators

Unlike traditional hyaluronic acid fillers, which primarily restore lost volume without improving skin structure, Lenisna enhances both volume and skin quality. Compared to other polylactic acid-based injectables, Lenisna has a lower risk of nodules and granulomas, as its PDLLA microparticles are more refined and evenly distributed. This makes it a safer, more predictable treatment for both younger and mature skin types.