MCE (Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate)

What Is MCE?

MCE is a next-generation chemical sunscreen filter developed to address a critical gap in sun protection: UVA1 radiation between 370 and 400 nm. Short for Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate, MCE belongs to the cyclic merocyanine class and was created through a collaboration between L’Oréal and BASF. It is marketed under the name Mexoryl 400 in select L’Oréal products, but is not available in all regions.

With a peak absorption at 385 nm, MCE is one of the few sunscreen ingredients specifically designed to protect against ultra-long UVA rays, which are strongly implicated in photoaging, pigmentary disorders, and dermal damage.

How It Works

MCE absorbs UVA1 radiation and converts it into heat, preventing deep-penetrating rays from damaging the dermis. Most traditional UVA filters taper off around 370 nm, leaving the skin vulnerable to longer UVA wavelengths. The addition of MCE to sunscreen formulations extends protection across the entire UVA spectrum, including the high-risk UVA1 range.

In both in vitro models and clinical trials, MCE has shown the ability to reduce pigmentation, limit matrix metalloproteinase (MMP-1) activity, and help maintain epidermal and dermal integrity under sun exposure.

Key Features and Properties

  • Chemical Class: Cyclic merocyanine
  • Molecular Formula: C₁₇H₂₆N₂O₄
  • UV Absorption Peak: 385 nm
  • Solubility: Soluble in ethanol and other cosmetic solvents
  • Photostability: Extremely high (retains over 98% UV absorbance after simulated sunlight exposure)

UVA1 Protection and Clinical Benefits

Studies using 3D skin models and human volunteers have demonstrated:

  • Superior absorption coverage between 370–400 nm
  • Reduced UVA1-induced pigmentation and signs of skin aging
  • Less degradation of collagen and lower inflammatory response
  • Improved skin radiance and evenness, confirmed by both expert panels and consumer self-assessment
  • Protection from cellular-level DNA damage and oxidative stress

Regulatory Status

  • European Union: Approved for use in sunscreen and cosmetic formulations up to 3%
  • United States: Not approved by the FDA