When it comes to skincare, Polynucleotides (PN) and Polydeoxyribonucleotides (PDRN) are redefining what it means to heal and rejuvenate the skin. These DNA-based ingredients work at a cellular level to repair damage, making them some of the most exciting advancements in modern dermatology.

What Are PN and PDRN?

PN and PDRN are fragments of DNA derived from natural sources like salmon. While they sound similar, their differences lie in molecular size and function. PN consists of larger DNA fragments, focusing on skin hydration, elasticity, and long-term rejuvenation. On the other hand, PDRN is made up of smaller DNA fragments that specifically target wound healing, collagen synthesis, and reducing inflammation. This makes PDRN effective for repairing scars, calming redness, and improving skin texture after procedures.

The Science Behind Skin Healing

Think of PN and PDRN as your skin’s repair crew. These molecules send powerful signals to cells, encouraging them to regenerate, retain moisture, and produce collagen. While PN provides a hydration boost and strengthens the skin barrier, PDRN dives deeper to repair damaged tissue and address inflammation. Together, they create a comprehensive approach to skin repair and rejuvenation.

Where Have You Seen PN and PDRN?

If you’ve heard of Rejuran or noticed products labeled “salmon DNA” in Korean skincare, you’re already familiar with these ingredients. Rejuran is a popular PDRN-based injectable often used for skin repair and scar treatment, while PN-based products frequently show up in hydrating serums and creams aimed at plumping and brightening the skin. Look for formulations that combine these ingredients with complementary actives like hyaluronic acid for even better results.

The Bottom Line

PN and PDRN represent a new frontier in skincare. These DNA-based treatments don’t just mask imperfections—they help your skin heal and strengthen itself. Whether through topical products or in-office treatments, they offer a personalized and effective way to achieve smoother, firmer, and healthier skin.